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Reversal of hypersplenism following orthotopic liver transplantation

Yanaga, K and Tzakis, AG and Shimada, M and Campbell, WE and Marsh, JW and Stieber, AC and Makowka, L and Todo, S and Gordon, RD and Iwatsuki, S and Starzl, TE (1989) Reversal of hypersplenism following orthotopic liver transplantation. Annals of Surgery, 210 (2). 180 - 183. ISSN 0003-4932

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The purpose of this study was to clarify the effect of orthotopic liver transplantation on hypersplenism. In a 1-year period from July 1, 1986 to June 30, 1987, 196 adult patients underwent 233 orthotopic liver transplantations. Of the 58 patients with hypersplenism who were analyzed in this study, hypersplenism was more commonly associated with postnecrotic cirrhosis than other kinds of liver disease (55.3% (47//85) vs. 14.5% (11/76); p < 0.001)). Postoperative platelet counts were statistically higher than preoperative values (p < 0.05). The latest platelet counts were more than 100,000/mm3 in 53 patients (91.4%). Of the eight patients whose preoperative and postoperative spleen volumes could be compared, all showed the reduction in the spleen size (p < 0.02). We conclude that orthotopic liver transplantation, which is a radical surgical procedure for portal hypertension, reverses hypersplenism.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Yanaga, K
Tzakis, AG
Shimada, M
Campbell, WE
Marsh, JW
Stieber, AC
Makowka, L
Todo, S
Gordon, RD
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Annals of Surgery
Volume: 210
Number: 2
Page Range: 180 - 183
DOI or Unique Handle: 10.1097/00000658-198908000-00007
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-4932
Other ID: uls-drl:31735062110568, Starzl CV No. 1015
Date Deposited: 08 Apr 2010 17:17
Last Modified: 22 Jun 2021 16:55


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