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Patterns of Drug Poisoning and Adverse Cardiovascular Disease Event Mortality in Pennsylvania

Printz, Olivia (2023) Patterns of Drug Poisoning and Adverse Cardiovascular Disease Event Mortality in Pennsylvania. Master Essay, University of Pittsburgh.

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Introduction: The objective of this essay was to identify the frequency and patterns of accidental drug poisoning and adverse cardiovascular disease event (ACVE) mortality in PA. Drug poisoning mortality has risen markedly over the last two decades. Several drugs involved in these deaths have known cardio-toxic effects. Yet, few reports have examined the trends in drug poisoning and ACVE in this time. This gap in knowledge needs to be further explored to examine patterns, trends, and risks.
Methods: A descriptive study was performed using data from CDC Wonder’s Multiple Cause of Death (final), 1999-2020 Results report. ICD-10 codes X40-X44 were used for accidental drug poisoning, I11, I25, and I46 were used for ACVE and T40.0-T40.7 were used for drug type to explore patterns and trends of accidental drug poisoning and ACVE deaths across time, race, gender, and age. Counts and crude rates were used to show these patterns and trends. Graphs were made using GraphPad Prism.
Results: Accidental drug poisoning and ACVE mortality has been on the rise since 1999 with a spike in 2016. Most deaths from drug poisoning and ACVE were due to cocaine and other synthetic narcotics. Black/African American and those aged 35-59 experience drug poisoning and ACVE deaths most in Pennsylvania. Males had a crude rate of 2.1 per 100,000, Black/African Americans had a crude rate of 2.4 per 100,000, those aged 50-54 had the highest crude rate at 3.3 per 100,000.
Discussion: The burden of drug poisoning and ACVE deaths falls primarily among those aged 35-59 years, Black/African Americans, and males. Males might have a higher mortality due to risk-taking behaviors, cardiovascular outcomes, and drug misuse. Drug poisoning and ACVE deaths saw a spike around 2016 possibly due to the availability of fentanyl and other drugs in the state.
Conclusion: Research studies need to be implemented to further explore the relationship between accidental drug poisoning and ACVE. With upward trends seen in the results of the study there is a public health need to understand the relationship of accidental drug poisoning and ACVE and to increase prevention efforts.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Printz, Oliviaolp20@pitt.eduolp20
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairSonger, Thomastjs@pitt.edutjsUNSPECIFIED
Committee MemberBuchanich, Jeaninejeanine@pitt.edujeanineUNSPECIFIED
Committee MemberGlynn, Nancyepidnwg@pitt.eduepidnwgUNSPECIFIED
Centers: Other Centers, Institutes, Offices, or Units > Center for Global Health
Date: 5 January 2023
Date Type: Completion
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 40
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 05 Jan 2023 14:52
Last Modified: 05 Jan 2023 14:52


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