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Marked Transient Alkaline Phosphatemia Following Pediatric Liver Transplantation

Koneru, B and Carone, E and Malatack, JJ and Esquivel, CO and Starzl, TE (1989) Marked Transient Alkaline Phosphatemia Following Pediatric Liver Transplantation. American Journal of Diseases of Children, 143 (6). 669 - 670. ISSN 0002-922X

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An isolated marked transient rise in serum alkaline phosphatase levels in otherwise healthy children is a well-documented occurrence. However, in children undergoing liver transplantation, elevated alkaline phosphatase values raise the possibility of biliary obstruction, rejection, or both. During a 6-year period, 6 of 278 children undergoing liver transplantation exhibited a similar phenomenon as an isolated abnormality. None had rejection, biliary obstruction, or other allograft dysfunction during a long follow-up. Eventually and without intervention, the alkaline phosphatase levels returned to normal. These instructive cases suggest that caution be used in advocating invasive procedures if elevated alkaline phosphatase levels are an isolated abnormality, and close observation with noninvasive testing is recommended. © 1989, American Medical Association. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Koneru, B
Carone, E
Malatack, JJ
Esquivel, CO
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: American Journal of Diseases of Children
Volume: 143
Number: 6
Page Range: 669 - 670
DOI or Unique Handle: 10.1001/archpedi.1989.02150180047018
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-922X
Other ID: uls-drl:31735062110584, Starzl CV No. 1017
Date Deposited: 08 Apr 2010 17:17
Last Modified: 02 Feb 2019 13:56


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