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Starzl, TE and Fung, J and Venkataramman, R and Todo, S and Demetris, AJ and Jain, A (1989) FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION. The Lancet, 334 (8670). 1000 - 1004. ISSN 0140-6736

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FK 506 was given for immunosuppression in 14 liver recipients. The drug was used in the first 10 cases because the recipients under conventional immunosuppression had rejection, nephrotoxicity, or both. This salvage therapy was successful in 7 of the 10 attempts. 2 of the 10 patients in the original salvage group as well as 4 new patients underwent fresh orthotopic liver transplantation under FK 506 plus low-dose steroids from the outset. None of these 6 patients had rejection although 1 with preexisting cor pulmonale and coronary atherosclerosis died of a myocardial infarction. In addition, 2 of the 14 liver recipients were given cadaveric kidneys, either from the same donor or from a different donor, and a third was given a pancreas as well as a kidney from the liver donor. There were no rejections of the kidney and pancreas grafts, and serious side-effects were not encountered. © 1989.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Fung, J
Venkataramman, R
Todo, S
Demetris, AJ
Jain, A
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 28 October 1989
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 334
Number: 8670
Page Range: 1000 - 1004
DOI or Unique Handle: 10.1016/s0140-6736(89)91014-3
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062110642, Starzl CV No. 1023
PubMed ID: 2478846
Date Deposited: 08 Apr 2010 17:17
Last Modified: 13 Dec 2017 19:55


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