Data files and other supplementary materials for Lefever et al., 2022 PMID: 35736460Lefever, Daniel (2022) Data files and other supplementary materials for Lefever et al., 2022 PMID: 35736460. [Dataset] AbstractThis data download includes supplementary data for Lefever DE, Miedel MT, Pei F, DiStefano JK, Debiasio R, Shun TY, Saydmohammed M, Chikina M, Vernetti LA, Soto-Gutierrez A, Monga SP, Bataller R, Behari J, Yechoor VK, Bahar I, Gough A, Stern AM, Taylor DL. A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies. Metabolites. 2022 Jun 7;12(6):528. doi: 10.3390/metabo12060528. PMID: 35736460; PMCID: PMC9227696. The following data are included in a zip file: differentially enriched pathways for each pairwise cluster and clinical classification comparison; DEGs resulting for each pairwise cluster and clinical classification comparisons; gene signatures used for CMap analysis; CMAP scores of small molecules with a DrugBank ID for the 24 queries described in the Methods; list of top 20 CMap predictions from both the 2017 and 2020 LINCS databases and both ranking methods (“Best score” and “Percentile score”) from the 24 signatures; degree of the nodes in the NAFLD subnetwork; network proximity-determined Z-scores for the highest ranking CMap-predicted drugs with targets mapping to the NAFLD subnetwork; DEGs resulting from the LAMPS pairwise comparisons (EMS vs. NF, LMS vs. NF, LMS vs. EMS); differentially enriched pathways the LAMPS pairwise comparisons (EMS vs. NF, LMS vs. NF, LMS vs. EMS); the 71 features selected by the final MLENet model; the differentially enriched pathways across 7 NAFLD categories for each pairwise cluster and clinical classification comparison; and NAFLD associated protein interactome. Data from experimental studies performed in this work are available at: https://mps.csb.pitt.edu/assays/assaystudyset/27/. The R analysis code for this study is available at: https://github.com/lefeverde/QSPpaper. Share
Details
MetricsMonthly Views for the past 3 yearsPlum AnalyticsAltmetric.comActions (login required)
|