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Effect of antiandrogen flutamide on measures of hepatic regeneration in rats

Svanas, GW and Eagon, PK and Elm, M and Makowka, L and Podesta, L and Chapchap, P and Kahn, D and Starzl, TE and Van Thiel, DH (1989) Effect of antiandrogen flutamide on measures of hepatic regeneration in rats. Digestive Diseases and Sciences, 34 (12). 1916 - 1923. ISSN 0163-2116

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Abstract

Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative response was investigated. Adult male Wistar rats were treated with the antiandrogen flutamide (2 mg/rat/day or 5 mg/rat/day subcutaneously) or vehicle for three days prior to and daily after a 70% partial hepatectomy. At various times after hepatectomy, the liver remnants were removed and weighed. Rates of DNA and polyamine synthesis were assessed by measuring thymidine kinase and ornithine decarboxylase activities, respectively. Hepatic estrogen receptor status and the activity of alcohol dehydrogenase, an androgen-sensitive protein, were measured. Prior to surgery, the administration of 5 mg/day flutamide reduced the hepatic cytosolic androgen receptor activity by 98% and hepatic cytosolic estrogen receptor content by 92% compared to that present in vehicle-treated controls. After hepatectomy, however, all differences in sex hormone receptor activity between the treatment groups were abolished. The rate of liver growth after partial hepatectomy in the three groups was identical. Moreover, hepatectomy-induced increases in ornithine decarboxylase activity and thymidine kinase activity were comparable. These data demonstrate that, although flutamide administration initially alters the sex hormone receptor status of the liver, these affects have no effect on the hepatic regenerative response following a partial hepatectomy. © 1989 Plenum Publishing Corporation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Svanas, GW
Eagon, PK
Elm, M
Makowka, L
Podesta, L
Chapchap, P
Kahn, D
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 December 1989
Date Type: Publication
Journal or Publication Title: Digestive Diseases and Sciences
Volume: 34
Number: 12
Page Range: 1916 - 1923
DOI or Unique Handle: 10.1007/bf01536712
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0163-2116
Other ID: uls-drl:31735062110725, Starzl CV No. 1030
Date Deposited: 08 Apr 2010 17:17
Last Modified: 02 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/4416

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