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Multivisceral intestinal transplantation: Surgical pathology

Jaffe, R and Trager, JDK and Zeevi, A and Sonmez-Alpan, E and Duquesnoy, R and Todo, S and Rowe, M and Starzl, TE (1989) Multivisceral intestinal transplantation: Surgical pathology. Fetal and Pediatric Pathology, 9 (6). 633 - 654. ISSN 1551-3815

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We report the diagnostic surgical pathology of two children who underwent multivisceral abdominal transplantation and survived for 1 month and 6 months. There is little relevant literature, and diagnostic criteria for the various clinical possibilities are not established; this is made more complicated by the simultaneous occurrence of more than one process. We based our interpretations on conventional histology, augmented with immunohistology, including HLA staining that distinguished graft from host cells in situ. In some instances functional analysis of T cells propagated from the same biopsies was available and was used to corroborate morphological interpretations. A wide spectrum of changes was encountered. Graft-versus-host disease, a prime concern before surgery, was not seen. Rejection was severe in 1 patient, not present in the other, and both had evidence of lymphoproliferative disease, which was related to Epstein-Barr virus. Bacterial translocation through the gut wall was also a feature in both children. This paper documents and illustrates the various diagnostic possibilities.. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Jaffe, R
Trager, JDK
Zeevi, A
Sonmez-Alpan, E
Duquesnoy, R
Todo, S
Rowe, M
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Fetal and Pediatric Pathology
Volume: 9
Number: 6
Page Range: 633 - 654
DOI or Unique Handle: 10.3109/15513818909022372
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1551-3815
Other ID: uls-drl:31735062110733, Starzl CV No. 1031
Date Deposited: 08 Apr 2010 17:17
Last Modified: 04 Feb 2019 15:57


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