Gao, Peng
(2023)
Investigating the Environmental Exposure Risks of Asthma.
In: Pitt Momentum Fund 2023.
Abstract
Genetics alone only accounts for 10-30% of the risks for human complex diseases while environmental factors contribute to the rest. Although extensive studies have evaluated human genetics, environmental exposures have been minimally investigated. Asthma is a common disease, which develops due to complex interactions of genetic and environmental factors, with genetics only contributing as lowest as 25% to the pathobiology. My long-term research goal is to deeply profile personal external and internal exposures and leverage them to investigate the molecular etiology of idiopathic and chronic diseases such as asthma. In this proposal, we aim to determine the environmental exposure risks for asthma severity and control by utilizing cutting-edge technologies in analytical chemistry, molecular epidemiology, and cellular biology. The central hypothesis of this proposed study is that certain xenobiotics contribute to asthma severity and control by mediating known asthma-related internal biomolecules. The expected outcomes are the revealed associations between xenobiotics exposures and asthma biomarkers by presenting the validated mediations through the internal biomolecules in the context of asthma severity and control. These results will be the essential preliminary data for my first NIH R01 proposal once finished and will significantly benefit the fields of severe asthma and environmental pathobiology.
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