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Transplantation in HIV<sup>+</sup> patients

Tzakis, AG and Cooper, MH and Dummer, JS and Ragni, M and Ward, JW and Starzl, TE (1990) Transplantation in HIV<sup>+</sup> patients. Transplantation, 49 (2). 354 - 358. ISSN 0041-1337

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Abstract

Twenty-five whole-organ recipients treated from 1981 through September 1988 were HIV carriers. Eleven were infected before transplantation, although this was not known until later in 8 recipients. The other 14 were infected perioperatively. Ten of the 25 recipients were infants or children. The organs transplanted were the liver (n = 15), and the heart or kidney (n = 5, each). After a mean follow-up of 2.75 years (range, 0.7- 6.6 years), 13 recipients are alive. Survival is 7/15, 2/ 5, and 4/5 of the liver, heart, and kidney recipients, respectively. The best results were in the pediatric group (70% survival) in which only 1 of 10 patients died of AIDS. In contrast, AIDS caused the death of 5 of 15 adult recipients and was the leading cause of death. Transplantation plus immunosuppression appeared to shorten the AIDS-free time in HIV < sup > + < /sup > patients as compared to nontransplant hemophiliac and transfusion control groups. Accrual of HIV+ transplant recipients has slowed markedly since the systematic screening of donors, recipients, and blood products was begun in 1985. © 1990 by Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tzakis, AG
Cooper, MH
Dummer, JS
Ragni, M
Ward, JW
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 49
Number: 2
Page Range: 354 - 358
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062110923, Starzl CV No. 1050
Date Deposited: 08 Apr 2010 17:18
Last Modified: 13 Oct 2017 19:55
URI: http://d-scholarship.pitt.edu/id/eprint/4436

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