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The hepatotropic influence of cyclosporine

Mazzaferro, V and Porter, KA and Scotti-Foglieni, CL and Venkataramanan, R and Makowka, L and Rossaro, L and Francavilla, A and Todo, S and Van Thiel, DH and Starzl, TE (1990) The hepatotropic influence of cyclosporine. Surgery, 107 (5). 533 - 539. ISSN 0039-6060

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Abstract

The effect of cyclosporine on liver regeneration has been investigated in 25 dogs that underwent an end-to-side portacaval shunt (Eck fistula) followed by 4 days continuous infusion of the drug into the left branch of the portal vein. Three different cyclosporine infusion rates were used: 0.06, 0.6, and 4.0 mg/kg/day. Control animals received the intravenous vehicle of cyclosporine at the same rate as the treated animals; a second control group received insulin, 0.42 units/kg/day. Hepatocyte 3 H-thymidine-labeled mitoses (index of hyperplasia) and hepatocyte volume (index of hypertrophy) were studied in the left (infused) and right (control) lobes in each animal. Cyclosporine vehicle had no measurable effect on hepatocytes that suffered typical atrophy and moderate increase in mitotic index after the Eck fistula. Cyclosporine infusion stimulated cell renewal significantly and restored hepatocyte size in the infused lobes with a dose-response relation. Similar positive effects were observed in the right (nonperfused) lobes, although they were less than those in the left (infused) lobes. This was because of an unmistakable spillover of cyclosporine from the infused lobes, especially in the large-dose group. No sign of hepatotoxicity was detected at any cyclosporine infusion rate. Cyclosporine has a remarkable hepatotropic effect that may be helpful in the context of liver transplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Mazzaferro, V
Porter, KA
Scotti-Foglieni, CL
Venkataramanan, Rrv@pitt.eduRV
Makowka, L
Rossaro, L
Francavilla, A
Todo, S
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 107
Number: 5
Page Range: 533 - 539
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062111004, Starzl CV No. 1059
Date Deposited: 08 Apr 2010 17:18
Last Modified: 01 Nov 2017 14:07
URI: http://d-scholarship.pitt.edu/id/eprint/4445

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