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Retrospective on Structure Activity Relationships with a Focus on Tamoxifen in the Treatment of Breast Cancer

Weiss, Colleen Marie (2023) Retrospective on Structure Activity Relationships with a Focus on Tamoxifen in the Treatment of Breast Cancer. Master Essay, University of Pittsburgh.

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Breast cancer is the most common cancer in the United States and worldwide. In women, it is the second leading cause of cancer deaths. Tamoxifen, a selective estrogen receptor modulator, has traditionally been used in the treatment and prevention of breast cancer.
Tamoxifen’s triphenylethylene structure activity relationship has been studied to evaluate the correlation between its chemical structure and biological activity. This essay focuses on tamoxifen for the treatment of breast cancer, analyzing its structure activity relationships,
associated potential risks (ie. carcinogenicity and mutagenicity) and alternatives.
Through computer-aided structure activity animal models in 1995, tamoxifen was predicted as a carcinogen. Databases were used for each endpoint based on structural alerts. Since then, epidemiological studies have supported the endometrial carcinogenicity of tamoxifen.
Structure activity relationship analyses have proved useful in the risk assessment of tamoxifen. And structure activity relationship models have evolved along with technology. However, there is still room for improvement in decreasing risk to those undergoing breast cancer treatment and preventing new cases. In the discussion, recommendations are made to oncologists on tamoxifen risk, breast cancer treatment options and prevention.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Weiss, Colleen Mariecmw237@pitt.educmw237
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairPeterson, Jamesjimmyp@pitt.edujimmypUNSPECIFIED
Committee MemberGeorge, Bandikbandik@pitt.edubandikUNSPECIFIED
Date: 17 May 2023
Date Type: Completion
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 44
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Environmental and Occupational Health
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 17 May 2023 14:06
Last Modified: 17 May 2023 14:06


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