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Outcomes in Patients with Alcoholic Hepatitis May be Affected by When an Infection is Presented

Ravi, Samhita (2023) Outcomes in Patients with Alcoholic Hepatitis May be Affected by When an Infection is Presented. Master's Thesis, University of Pittsburgh. (Unpublished)

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Alcohol-associated hepatitis is a severe condition in patients with heavy alcohol use. It is characterized by acute onset of jaundice, and complications such as ascites and hepatic encephalopathy (1). These patients often develop bacterial infections which can negatively impact their outcomes (2). When the infection was acquired relative to being admitted to the hospital can possibly predict negative outcomes including intubation, development of septic shock, and multiorgan failure. We hypothesize that patients with alcohol-associated hepatitis who present with an infection at admission versus those that develop infection during hospitalization have different clinical outcomes. Overall, there is no difference between the two groups among the different clinical outcomes. Furthermore, there are more infections presented at admission than developed during hospitalization. These findings may indicate that the University of Pittsburgh Medical Center may place great importance on infection control and preventing hospital acquired infections. While this is the case, this study suggests that outside hospitals should focus on preventing infections in their facilities to prevent poor outcomes in patients when transferred to other hospital systems.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Ravi, SamhitaSAR160@pitt.eduSAR160
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairMartinson, Jeremyjmartins@pitt.edujmartins
Committee MemberCarlson, Jennajnc35@pitt.edujnc35
Committee MemberMailliard, Robbierbm19@pitt.edurbm19
Date: 15 May 2023
Date Type: Publication
Defense Date: 4 April 2023
Approval Date: 15 May 2023
Submission Date: 23 April 2023
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 29
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Alcoholic Hepatitis, Infections, Clinical Outcomes
Date Deposited: 15 May 2023 22:36
Last Modified: 15 May 2023 22:36


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