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Relationship between extracranial carotid artery calcification and β-amyloid deposition in the brain among the very old: a retrospective study

Jiatong, Li (2023) Relationship between extracranial carotid artery calcification and β-amyloid deposition in the brain among the very old: a retrospective study. Master Essay, University of Pittsburgh.

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Background/Objective: Extracranial carotid artery calcification (ECAC) is a risk factor for the development of cardiovascular diseases (CVD). Previous studies showed that ECAC was associated with a higher risk of dementia. Amyloid-β (Aβ) plays a key role in Alzheimer’s disease development. The relationship between ECAC and Aβ in the elderly population is unclear. This study aims to determine the relationship between ECAC and Aβ deposition in very old adults. Methods: Ginkgo Evaluation of Memory Study (GEMS), is a multi-center randomized clinical trial (U01AT000162), carried out in Pittsburgh from 2000 to 2008. Demographic information with baseline CVD status was collected at the start of the trial. After the trial ended, 193 participants without dementia were recruited into the GEMS imaging sub-study in 2009. C11-labeled Pittsburgh compound-B positron emission tomography (PiB-PET) scans were performed in 2009 and 2011 to detect Aβ deposition in the brain. In 2010-2011, 98 participants had carotid ultrasound scans by which ECAC was detected. Multivariable logistic regression was performed to assess the association between ECAC and Aβ positivity adjusting for demographic and CVD risk factors. Results: 90 participants (mean ± sd, 87.2 ± 2.7 years old) completed both carotid ultrasound and PiB-PET scans, 82 (91%) had carotid plaques, and 60 (73%) were Aβ positive in 2011. ECAC was less frequently detected in the Aβ positive group compared to the Aβ negative group (82% versus 95%, p=0.17). The risk of Aβ positivity in the old population with ECAC was 80% lower compared with participants without ECAC. However, the relationship was not statistically significant (OR= 0.20, 95% CI: [0.01,1.47], p=0.2). Conclusion: In the very old population, those with ECAC tended to have a lower prevalence of Aβ deposition. These unexpected findings merit further exploration. ECAC status in the very old population might be one of the potential markers in future public health studies related to Alzheimer’s disease prevention and the clinical trial focusing on Aβ deposition.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Jiatong, Lijil292@pitt.edujil2920000-0003-3778-5633
ContributionContributors NameEmailPitt UsernameORCID
Thesis advisorSekikawa, Akiraakira@pitt.eduakiraUNSPECIFIED
Committee MemberLopez, Oscar Llopezol@upmc.eduUNSPECIFIEDUNSPECIFIED
Committee MemberBarinas-Mitchell, Emmabarinas@edc.pitt.edubarinasUNSPECIFIED
Committee MemberChang, Yuefangyuc2@pitt.eduyuc2UNSPECIFIED
Date: 17 May 2023
Date Type: Completion
Submission Date: 26 April 2023
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 45
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: Extracranial carotid artery calcification (ECAC), Amyloid-β (Aβ), Alzheimer’s disease
Date Deposited: 17 May 2023 19:14
Last Modified: 17 May 2023 19:14


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