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Genetic Polymorphisms in LRP1, a Newly Identified Receptor for Emerging Bunyaviruses

Fields, Bayley N (2023) Genetic Polymorphisms in LRP1, a Newly Identified Receptor for Emerging Bunyaviruses. Master Essay, University of Pittsburgh.

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Bunyaviruses, such as Rift Valley Fever (RVFV), are becoming increasingly important in public health. RVFV is being prioritized by the World Health Organization (WHO) due to its potential to become an epidemic. RVFV is transmitted by mosquitos and has the potential to spread to new areas due to climate change. There is no treatment for RVFV since many aspects of the disease are still unknown. Recently, a surface receptor known as low-density lipoprotein receptor-related protein 1 (LRP1) was identified as a factor in RVFV cellular uptake. This finding could be important for progression and may be a potential target for drug therapies or vaccines. Polymorphisms in the human LRP1 gene have been documented and are associated with adverse outcomes such as cholesterol and cardiovascular diseases. We hypothesize that polymorphisms in LRP1 may affect protein expression, function, and/or structure, which could then affect the susceptibility of cells to infection by RVFV. We identified nine polymorphisms of interest: rs138854007, rs1799986, rs1800127, rs1800137, rs34577247, rs1800194, rs12814239, and rs7397167. RVFV is an infectious disease that can lead to serious health outcomes in infected people. As climate change results in disease-carrying mosquitos spreading to other areas, more people will be exposed. Without effective treatment or vaccine, this could seriously impact human health. LRP1 could be significant in RVFV disease progression; therefore, it could be a valuable avenue for treatment or vaccine development. Polymorphisms influencing LRP1 function could be significant in understanding susceptibility to RVFV infection and clinical disease progression.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Fields, Bayley Nbnf18@pitt.edubnf18
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairHartman, Amy Lhartman2@pitt.eduhartman2UNSPECIFIED
Committee MemberMartinson, Jeremyjmartins@pitt.edujmartinsUNSPECIFIED
Committee MemberBinder, Robertrjb42@pitt.edurjb42UNSPECIFIED
Date: 16 May 2023
Date Type: Completion
Number of Pages: 47
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 16 May 2023 18:58
Last Modified: 16 May 2023 18:58


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