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24-hour movement behaviors and cognitive performance in older adults: a compositional and isotemporal reallocation analysis

Shi, Hui (2023) 24-hour movement behaviors and cognitive performance in older adults: a compositional and isotemporal reallocation analysis. Master's Thesis, University of Pittsburgh. (Unpublished)

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Background: Previous research found beneficial health effects of 24-hour movement behaviors (sleep, sedentary activity, light-intensity physical activity (LIPA), and moderate-to-vigorous intensity physical activity (MVPA)) on cognition, however, these studies analyzed the relationship between these behaviors and cognition in isolation, which could lead to bias in the interpretation since the behaviors are inter-related. In this study, we aimed to be the first to disentangle the relationship between objectively measured 24-hour movement behaviors and cognitive performance among older men using a compositional data analysis approach.
Methods: The study was a cross-sectional secondary data analysis of the Osteoporotic Fractures in Men Study (MrOS), with 2,981 men (median age: 78 years) enrolled from visit 3. 24-hour movement behaviors were measured by wearing the activity monitor (SenseWear® Pro3 Armband) on their right arm for seven days. Cognitive function was assessed by the Modified Mini-Mental Status (3MS) examination and Part B of the Trail Making Test (Trails B test) tools. Multiple linear regressions were used to test the relationship between the 24-hour movement behaviors and cognition performance using the isotemporal substitution regression model (ISM) and compositional data analysis (CoDA) approaches.
Results: In ISM, replacing 30 min/day of sedentary activity with sleep was deleteriously associated with poorer global cognitive function (β= 0.010; 95% CI= 0.000, 0.020) and poorer executive cognitive function (β= 0.009; 95% CI= 0.003, 0.014). Replacing 30 min/day of LIPA with sleep (β= 0.046; 95% CI= 0.027, 0.065), sedentary activity (β= 0.038; 95% CI= 0.019, 0.057), and MVPA (β= 0.041; 95% CI= 0.015, 0.068) resulted in poorer executive cognitive function. In CoDA, reallocating 30 min/d from sedentary activity to sleep were associated with poorer global cognitive function (effect size (ES), ES=0.007; 95% CI=0.038, 0.063) and worse executive cognitive function (ES=0.005; 95% CI=0.004, 0.006), but reallocating 30 min/d from sedentary activity to LIPA (ES= -0.008; 95% CI= -0.019, -0.003) and MVPA (ES= -0.011; 95% CI= -0.012, -0.005) was beneficially associated with predicted global cognitive function.
Conclusions: Our results suggest an integrated role of 24-hour movement behaviors on cognition, and suggest that physical activity, particularly LIPA, plays an important role in delaying cognitive decline among older adults.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Shi, Huihus38@pitt.eduhus38
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairHawkins, Marquismah400@pitt.edumah400
Committee MemberRockette-Wagner, Bonnybjr26@pitt.edubjr26
Committee MemberSoehner,
Date: 11 May 2023
Date Type: Publication
Defense Date: 15 March 2023
Approval Date: 11 May 2023
Submission Date: 28 April 2023
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 69
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: 24-hour movement behaviors; sleep; sedentary activity; light-intensity physical activity; moderate-to-vigorous intensity physical activity; cognition; isotemporal substitution regression model; compositional data analysis
Date Deposited: 11 May 2023 16:30
Last Modified: 11 May 2023 16:30


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