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Obesity as a risk factor following cadaveric renal transplantation

Holley, JL and Shapiro, R and Lopatin, WB and Tzakis, AG and Hakala, TR and Starzl, TE (1990) Obesity as a risk factor following cadaveric renal transplantation. Transplantation, 49 (2). 387 - 389. ISSN 0041-1337

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Abstract

Obesity has generally been thought to increase the risk of operative mortality and postoperative complications in surgical patients. No data examining obesity as a factor in cadaveric renal transplantation were available. We therefore matched obese patients undergoing cadaveric renal transplantation with nonobese control patients and retrospectively analyzed mortality, morbidity, and graft survival in each group. Patients were matched for age, sex, diabetes mellitus, PRA, graft number, cardiovascular disease, date of transplantation, and posttransplant immunosuppression. There were significant differences found in mortality (11% in obese vs. 2% in nonobese patients, P < 0.01), immediate graft function (38% in obese vs. 64% in nonobese patients, P < 0.01), 1-year graft survival (66% in obese vs. 84% in nonobese patients, P < 0.05), and postoperative complications. Wound complications (20% vs. 2%, P < 0.01), intensive-care-unit admissions (10% vs. 2%, P < 0.01), reintubations (16% vs. 2%, P < 0.03), and new-onset diabetes (12% vs. 0%, P < 0.02) were all significantly more common in the obese group. These results suggest that an attempt at significant weight reduction is indicated in obese patients prior to renal transplantation. © 1990 by Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Holley, JL
Shapiro, R
Lopatin, WB
Tzakis, AG
Hakala, TR
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 49
Number: 2
Page Range: 387 - 389
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062116516, Starzl CV No. 1097
Date Deposited: 08 Apr 2010 17:18
Last Modified: 13 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/4483

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