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Suppression of allograft rejection with FK506: I. prolonged cardiac and liver survival in rats following short-course therapy

Murase, N and Kim, DG and Todo, S and Cramer, DV and Fung, JJ and Starzl, TE (1990) Suppression of allograft rejection with FK506: I. prolonged cardiac and liver survival in rats following short-course therapy. Transplantation, 50 (2). 186 - 189. ISSN 0041-1337

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Abstract

Heterotopic heart and orthotopic liver grafts from ACI donors were transplanted to Lewis rat recipients that were treated with a 3 (or 4) day course of FK506 IM that was started on postoperative day 0, 2, 3, 4, 5, or 6. Hearts, which rejected after a median of 6 days in untreated controls, always had prolonged survival (median 91 days) when treatment was started on postoperative day 4. The results were inferior when treatment was started earlier or later than this, but even when the first dose of FK506 was on postoperative day 5, one day before rejection was imminent in controls, the median survival was 50 days. The poorest results with a median graft survival of only 36 days were obtained when injections were on days 0–3. Results were similar with liver grafts that rejected after a median time of 10 days in nontreated controls but that usually survived permanently after a 3 (or 4) day FK506 course starting on day 0, 2, 3, or 4. Therapy started on day 6 was too late. © 1990 by Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Murase, N
Kim, DG
Todo, S
Cramer, DV
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 50
Number: 2
Page Range: 186 - 189
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062116540, Starzl CV No. 1100
Date Deposited: 08 Apr 2010 17:18
Last Modified: 13 Oct 2017 20:56
URI: http://d-scholarship.pitt.edu/id/eprint/4486

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