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Orthotopic liver transplantation for alcoholic liver disease

Kumar, S and Stauber, RE and Gavaler, JS and Basista, MH and Dindzans, VJ and Schade, RR and Rabinovitz, M and Tarter, RE and Gordon, R and Starzl, TE and Van Thiel, DH (1990) Orthotopic liver transplantation for alcoholic liver disease. Hepatology, 11 (2). 159 - 164. ISSN 0270-9139

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Alcohol abuse is the most common cause of end‐stage liver disease in the United States, but many transplant centers are unwilling to accept alcoholic patients because of their supposed potential for recidivism, poor compliance with the required immunosuppression regimen and resulting failure of the allograft. There is also concern that alcohol‐induced injury in other organs will preclude a good result. From July 1, 11982, to April 30, 1988, 73 patients received orthotopic liver transplants at the University of Pittsburgh for end‐stage alcoholic liver disease. Fifty‐two (71%) of these were alive at 25 ± 9 mo (mean ± S. D.) after transplantation, when a phone survey of these patients, their wives/husbands, and their physicians was performed to evaluate their subsequent use of alcohol, current medical condition and employment. Data obtained were compared with those for nonalcoholic patients selected as transplant controls. The recidivism rate has been 11.5%, with most patients drinking only socially. Fifty‐four percent of the survivors are employed, 21% classify themselves as homemakers and only 11 (21%) are unable to work. Twenty‐one patients died after transplantation; the most frequent cause of death was sepsis (43%), and intraoperative death was the next most common cause (28.6%). These data demonstrate that alcoholic patients can be transplanted successfully and achieve good health not significantly different from that of individuals transplanted for other causes. Thus orthotopic liver transplantation is a therapeutic option that should be considered for individuals with end‐stage alcoholic liver disease who desire such therapy. Copyright © 1990 American Association for the Study of Liver Diseases


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kumar, S
Stauber, RE
Gavaler, JS
Basista, MH
Dindzans, VJ
Schade, RR
Rabinovitz, M
Tarter, REtarter@pitt.eduTARTER
Gordon, R
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 11
Number: 2
Page Range: 159 - 164
DOI or Unique Handle: 10.1002/hep.1840110202
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062116581, Starzl CV No. 1104
Date Deposited: 08 Apr 2010 17:18
Last Modified: 02 Feb 2019 13:55


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