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Badziai, Anastasiya (2023) CCL2’S IMMUNOMODULATORY ROLE IN THE TREATMENT OF PERI-IMPLANTITIS IN A MURINE MODEL. Master's Thesis, University of Pittsburgh. (Unpublished)

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Peri-implantitis (PI) is a plaque-associated inflammatory disease that results in soft tissue destruction and loss of supporting bone around osseointegrated dental implants. Tissue breakdown is mediated by the components of innate and acquired immune systems such as immune cells, cytokines, chemokines and other mediators. Therefore, the key to managing peri-implantitis may be in focusing on local immune cellular event and its agents. Current treatment options include resective and regenerative approach involving a wide array of decontaminative techniques, graft materials and biologics. High cost, invasiveness, high morbidity and the lack of predictability dictate the need for further research in this direction. Recent evidence demonstrated that immunomodulation in the oral cavity may offer a radically new treatment modality. By modulating the host’s immune response, we propose to develop a novel therapeutic method to prevent peri-implantitis. We first developed a murine peri-implantitis model at the University of Pittsburgh to facilitate this goal. PLGA microspheres (MPs) encapsulating CCL2 (CCL2 MPs) chemokine ligand were fabricated to provide sustained release. The therapeutic effects of CCL2 were tested by injecting CCL2 MPs into soft tissues around the dental implant using a ligature-induced mouse peri-implantitis model. The goal of this study was to test the feasibility of local delivery of CCL2 MPs as a potential therapy for inflammatory bone loss in peri-implantitis.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Badziai, Anastasiyaanb293@pitt.eduanb293
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSfeir, Charlescsfeir@pitt.educsfeir
Committee MemberIntini, Giuseppegii5@pitt.edugii5
Committee MemberWilliams, Kellykellywilliams@pitt.edukellywilliams
Date: 1 July 2023
Date Type: Publication
Defense Date: 16 May 2023
Approval Date: 1 July 2023
Submission Date: 1 June 2023
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 53
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MDS - Master of Dental Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: peri-implantitis, immunomodulation, CCL2, inflammation
Date Deposited: 01 Jul 2023 13:33
Last Modified: 01 Jul 2023 13:33


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