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Liver, kidney, and thoracic organ transplantation under FK 506

Todo, S and Fung, JJ and Starzl, TE and Tzakis, A and Demetris, AJ and Kormos, R and Jain, A and Alessiani, M and Takaya, S and Shapiro, R (1990) Liver, kidney, and thoracic organ transplantation under FK 506. Annals of Surgery, 212 (3). 295 - 307. ISSN 0003-4932

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The new immunosuppressive drug FK 506 was used from the outset with low doses of prednisone to treat 120 recipients of primary liver grafts and 20 more patients undergoing liver retransplantation. The patient survival rate after 2 to 8 months in the primary liver transplantation series is 93.3%, with original graft survival of 87.5%. Of the 20 patients in the hepatic retransplant series, 17 (85%) are living. Almost all of the surviving patients have good liver function. In addition 11 hearts, 2 double lungs, and a heart-lung have been transplanted under FK 506, with survival of all 14 patients. With all of the organ systems so far tested, including the kidney (which has been reported elsewhere), rejection usually has been controlled without additional drugs and with lower average steroid doses than in the past. Nephrotoxicity has been observed, but not to an alarming degree, and there has been a notable absence of hypertension. There is a suggestion that serum cholesterol may be lowered by FK 506, but this is unproved. Although the adverse reactions of FK 506 and the immunosuppressive mechanisms resemble those of cyclosporine, our preliminary observations suggest that FK 506 may have a more advantageous therapeutic index.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Tzakis, A
Demetris, AJ
Kormos, Rkormos@pitt.eduKORMOS
Jain, A
Alessiani, M
Takaya, S
Shapiro, R
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Annals of Surgery
Volume: 212
Number: 3
Page Range: 295 - 307
DOI or Unique Handle: 10.1097/00000658-199009000-00008
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-4932
Other ID: uls-drl:31735062116623, Starzl CV No. 1108
Date Deposited: 08 Apr 2010 17:18
Last Modified: 21 Jun 2020 10:55


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