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Viswanathan, Anupama and Sfeir, Charles and Ki, Yejin (2023) CCL22'S IMMUNOMODULATORY ROLE IN THE PREVENTION OF PERI-IMPLANTITIS IN A MURINE MODEL. Master's Thesis, University of Pittsburgh. (Unpublished)

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Peri-implantitis(PI) is defined as a pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri‐implant connective tissue and progressive loss of supporting bone(Schwarz et al.) Peri‐implantitis could start early after implant placement and shows a non‐linear and accelerating pattern of progression. Peri-Implantitis (PI) is one of the main reasons for complications and subsequent implant loss (Kang et al.; Olmedo-Gaya et al.; Sakka et al.). Approximately 22% (weighted mean prevalence) of the population that has received dental implants has suffered from peri-implantitis(Derks and Tomasi). The treatment protocol includes non-surgical mechanical treatment alone or with adjunctive therapy (i.e., local antibiotics, antimicrobial photodynamic therapy—aPDT) or alternative measures (e.g., air abrasive devices, erbium-doped yttrium aluminum garnet—Er:YAG laser monotherapy). These have limited efficacy in obtaining disease resolution. Hence, patients diagnosed with peri-implantitis are often subjected to surgical therapy which includes various surface decontamination approaches, resective measures (e.g., apical flap, osteoplasty, implantoplasty), reconstructive surgeries (e.g., bone graft/ autografts, guided bone regeneration), or a combined therapy(Ramanauskaite et al.). Currently, no one approach is considered the most effective in the treatment of peri-implantitis. Recent evidence has demonstrated that immunomodulation in the oral cavity can be beneficial in peri-apical lesions and periodontitis.(Francisconi et al.; Glowacki et al.; He et al.) By modulating the host’s immune response, we propose to develop a novel therapeutic method to prevent peri-implantitis. This investigation evaluated the effects of the C-C motif chemokine ligand 22 (CCL22) on host immunomodulation in a murine ligature-induced peri-implantitis model. PLGA microspheres (MPs) encapsulating CCL22 (CCL22 MPs) will be fabricated to provide sustained release. We will test the therapeutic effects of CCL22 by injecting CCL22 MPs into soft tissues around the dental implant using a ligature-induced mouse peri-implantitis model. The goal of this study is to test the feasibility of local delivery of CCL22 MPs as a potential therapy for inflammatory bone loss in peri-implantitis.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Viswanathan, Anupamaanv74@pitt.eduAnv74
Sfeir, Charlescsfeir@pitt.educsfeir
Ki, Yejinyek15@pitt.eduyek15
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSfeir, Charlescsfeir@pitt.educsfeir
Committee MemberIntini, Giuseppegii5@pitt.eduGii5
Committee MemberWilliams, Kellykellywilliams@pitt.eduklb31
Date: 1 July 2023
Date Type: Publication
Defense Date: 16 May 2023
Approval Date: 1 July 2023
Submission Date: 7 June 2023
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 45
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MDS - Master of Dental Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: CCL22, Immunomodulation, Inflammation, Peri-implantitis
Date Deposited: 01 Jul 2023 13:34
Last Modified: 01 Jul 2023 13:34


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