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Pancreatic islet transplantation after upper abdominal exeriteration and liver replacement

Tzakis, AG and Zeng, Y and Fung, JJ and Todo, S and Demetris, AJ and Starzl, TE and Mintz, DH and Alejandro, R and Ricordi, C (1990) Pancreatic islet transplantation after upper abdominal exeriteration and liver replacement. The Lancet, 336 (8712). 402 - 405. ISSN 0140-6736

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Abstract

Nine patients who became diabetic after upper-abdominal exenteration and liver transplantation were given pancreatic islet-cell grafts obtained from the liver donor (eight cases), a third-party donor (one), or both (four). Two patients were diabetic when they died of infections after 48 and 109 days, as was a third patient who died of tumour recurrence after 178 days. The other 6 are alive 101-186 days postoperatively, and five are insulin-free or on insulin only during night-time parenteral alimentation. C-peptide increased 1·7 to 3·3 fold in response to intravenous glucose in these five patients who have had glycosylated haemoglobin in the high normal range. However, the kinetics of the C-peptide responses to intravenous glucose in all eight patients tested revealed an absent first-phase release and a delayed peak response consistent with transplantation and/or engraftment of a suboptimal islet cell mass. The longest survivor, who requires neither parenteral alimentation nor insulin, is the first unequivocal example of successful clinical islet-cell transplantation. © 1990.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tzakis, AG
Zeng, Y
Fung, JJ
Todo, S
Demetris, AJ
Starzl, TEtes11@pitt.eduTES11
Mintz, DH
Alejandro, R
Ricordi, C
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 18 August 1990
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 336
Number: 8712
Page Range: 402 - 405
DOI or Unique Handle: 10.1016/0140-6736(90)91946-8
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062116730, Starzl CV No. 1119
Date Deposited: 08 Apr 2010 17:19
Last Modified: 13 Oct 2017 21:57
URI: http://d-scholarship.pitt.edu/id/eprint/4505

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