Tzakis, AG and Zeng, Y and Fung, JJ and Todo, S and Demetris, AJ and Starzl, TE and Mintz, DH and Alejandro, R and Ricordi, C
(1990)
Pancreatic islet transplantation after upper abdominal exeriteration and liver replacement.
The Lancet, 336 (8712).
402 - 405.
ISSN 0140-6736
Abstract
Nine patients who became diabetic after upper-abdominal exenteration and liver transplantation were given pancreatic islet-cell grafts obtained from the liver donor (eight cases), a third-party donor (one), or both (four). Two patients were diabetic when they died of infections after 48 and 109 days, as was a third patient who died of tumour recurrence after 178 days. The other 6 are alive 101-186 days postoperatively, and five are insulin-free or on insulin only during night-time parenteral alimentation. C-peptide increased 1·7 to 3·3 fold in response to intravenous glucose in these five patients who have had glycosylated haemoglobin in the high normal range. However, the kinetics of the C-peptide responses to intravenous glucose in all eight patients tested revealed an absent first-phase release and a delayed peak response consistent with transplantation and/or engraftment of a suboptimal islet cell mass. The longest survivor, who requires neither parenteral alimentation nor insulin, is the first unequivocal example of successful clinical islet-cell transplantation. © 1990.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Tzakis, AG | | | | | Zeng, Y | | | | | Fung, JJ | | | | | Todo, S | | | | | Demetris, AJ | | | | | Starzl, TE | tes11@pitt.edu | TES11 | | | Mintz, DH | | | | | Alejandro, R | | | | | Ricordi, C | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
18 August 1990 |
| Date Type: |
Publication |
| Journal or Publication Title: |
The Lancet |
| Volume: |
336 |
| Number: |
8712 |
| Page Range: |
402 - 405 |
| DOI or Unique Handle: |
10.1016/0140-6736(90)91946-8 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0140-6736 |
| Other ID: |
uls-drl:31735062116730, Starzl CV No. 1119 |
| Date Deposited: |
08 Apr 2010 17:19 |
| Last Modified: |
27 Jan 2019 02:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4505 |
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