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Cyclosporine measurement by FPIA, PC-RIA, and HPLC following liver transplantation

Burckart, GJ and Jain, A and Diven, W and Venkataramanan, R and Starzl, TE (1990) Cyclosporine measurement by FPIA, PC-RIA, and HPLC following liver transplantation. Transplantation Proceedings, 22 (3). 1319 - 1322. ISSN 0041-1345

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Abstract

The factors affecting CyA dosing and kinetics in LT patients are complex, and have been thoroughly investigated and reviewed. Plasma or WB CyA concentration monitoring remains the best method presently available for adjusting CyA dosage in LT patients in a timely manner. The availability of an FPIA assay for CyA has produced rapid drug analysis for transplant patient monitoring, but adds additional factors that must be considered in interpreting CyA concentrations. Liver dysfunction may disproportionately elevate CyA plasma or blood levels when analyzed by FPIA in relation to PC-RIA or HPLC, and adjustment of the therapeutic range or analysis by a more specific assay method may be necessary for dosage adjustment in these patients. The availability of a more specific antibody in an FPIA assay may avert these problems, as would the development of immunologic monitoring techniques that provide a global assessment of immune suppression produced by increasingly complex immunosuppressive regimens in LT patients.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Burckart, GJ
Jain, A
Diven, W
Venkataramanan, Rrv@pitt.eduRV
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Transplantation Proceedings
Volume: 22
Number: 3
Page Range: 1319 - 1322
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1345
Other ID: uls-drl:31735062116755, Starzl CV No. 1121
Date Deposited: 08 Apr 2010 17:19
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/4507

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