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Donor gender does not affect liver transplantation outcome in children

Pillay, P and Van Thiel, DH and Gavaler, JS and Starzl, TE (1990) Donor gender does not affect liver transplantation outcome in children. Digestive Diseases and Sciences, 35 (6). 686 - 689. ISSN 0163-2116

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The liver is recognized as a sex hormone-responsive organ. Gender-specific differences in liver function are known to exist. Recently, a higher failure rate for organs transplanted in adults from female donors to male recipients has been reported. This increased failure rate of livers obtained from adult females and transplanted into adult males is thought to occur, at least in part, as a result of intrinsic gender-specific differences in hepatocyte cell surface expression and to alterations in the hormonal milieu of the donor liver in the recipient. To determine whether the same graft-recipient gender-determined failure rates pertain in the pediatric liver transplant population, the outcome of 335 primary liver transplants performed in children at the University of Pittsburgh Medical Center was examined. No difference in transplant outcome was demonstrated in children based on the gender pairings between the donor and recipient whether or not variables such as the age, etiology of the liver disease, and the blood group of the recipient were included in the data analysis. Thus, in contrast, to the situation in adults, the gender of the donor does not influence the outcome of liver transplantation in children and should not be used as a criterion for donor selection. This difference between adults and children may be due, at least in part, to gender differences in hepatocyte phenotypic expression induced as a consequence of puberty. © 1990 Plenum Publishing Corporation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pillay, P
Van Thiel, DH
Gavaler, JS
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 June 1990
Date Type: Publication
Journal or Publication Title: Digestive Diseases and Sciences
Volume: 35
Number: 6
Page Range: 686 - 689
DOI or Unique Handle: 10.1007/bf01540167
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0163-2116
Other ID: uls-drl:31735062116821, Starzl CV No. 1129
Date Deposited: 08 Apr 2010 17:19
Last Modified: 02 Feb 2019 13:55


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