Yokoyama, I and Todo, S and Iwatsuki, S and Starzl, TE
(1990)
Liver transplantation in the treatment of primary liver cancer.
Hepato-Gastroenterology, 37 (2).
188 - 193.
ISSN 0172-6390
Abstract
One hundred and fifteen patients underwent orthotopic liver transplantation (OLT) for primary liver malignancy. Overall survivals of these patients were significantly lower than those of patients with non-malignant diseases (5-year survival rates 37% and 65%, respectively). Hepatocellular carcinoma (HCC) was the most common malignancy among our patients (n = 80). Fibrolamellar HCC (n = 9) was associated with better survival than non-fibrolamellar HCC (N = 71) among the lesions ≥5 cm in diameter. More frequent recurrence was noted in patients with large tumors (≥5 cm), multiple tumors, and gross vascular involvement. A significant lower survival rate was observed in patients with bile duct cancer (n = 19) than in those with HCC or epithelioid hemangioendothelioma (n = 8). Careful patient selection and effective adjuvant anticancer therapy are needed to improve the results of OLT for primary liver malignancy.
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