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Liver transplantation in the treatment of primary liver cancer

Yokoyama, I and Todo, S and Iwatsuki, S and Starzl, TE (1990) Liver transplantation in the treatment of primary liver cancer. Hepato-Gastroenterology, 37 (2). 188 - 193. ISSN 0172-6390

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One hundred and fifteen patients underwent orthotopic liver transplantation (OLT) for primary liver malignancy. Overall survivals of these patients were significantly lower than those of patients with non-malignant diseases (5-year survival rates 37% and 65%, respectively). Hepatocellular carcinoma (HCC) was the most common malignancy among our patients (n = 80). Fibrolamellar HCC (n = 9) was associated with better survival than non-fibrolamellar HCC (N = 71) among the lesions ≥5 cm in diameter. More frequent recurrence was noted in patients with large tumors (≥5 cm), multiple tumors, and gross vascular involvement. A significant lower survival rate was observed in patients with bile duct cancer (n = 19) than in those with HCC or epithelioid hemangioendothelioma (n = 8). Careful patient selection and effective adjuvant anticancer therapy are needed to improve the results of OLT for primary liver malignancy.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Yokoyama, I
Todo, S
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Hepato-Gastroenterology
Volume: 37
Number: 2
Page Range: 188 - 193
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0172-6390
Other ID: uls-drl:31735062116862, Starzl CV No. 1133
Date Deposited: 08 Apr 2010 17:19
Last Modified: 02 Feb 2019 13:55


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