Hepatotrophic effects of FK506 in dogs

Starzl, TE and Porter, KA and Mazzaferro, V and Todo, S and Fung, J and Francavilla, A (1991) Hepatotrophic effects of FK506 in dogs. Transplantation, 51 (1). 67 - 70. ISSN 0041-1337

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Abstract

Portacaval shunt (Eck fistula) in dogs causes hepato- cyte atrophy and organelle disruption, as well as tripling of hepatocyte mitoses. After submitting dogs to this pro-cedure, FK506 was infused into the tied-off left portal vein. The size, anatomic quality, and replication of he- patocytes were enhanced in the portion of liver infused with FK506, with a significant spillover effect in the noninfused portion. These hepatotrophic qualities of FK506 may explain part of FK506’s efficacy for the treatment of chronic liver rejection. Also, the observa-tions support a trial with this drug for the treatment of autoimmune liver diseases because, in addition to turning off the immunologic genesis of such disorders, repair and regeneration of the damaged liver may be augmented. Finally, these hepatrophic qualities are part of an emerging spectrum of biologic effects caused by drugs that may modulate the enzyme cis-trans peptidyl-prolyl isomerase (PPIase), the principal constituent of the cy-tosolic binding sites of FK506, repamycin, cyclosporine, and presumably other immunosuppressive drugs as yet undiscovered.© 1991 by Williams & Wilkins.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Starzl, TE tes11@pitt.edu TES11 Porter, KA Mazzaferro, V Todo, S Fung, J Francavilla, A
Centers:	Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date:	1 January 1991
Date Type:	Publication
Journal or Publication Title:	Transplantation
Volume:	51
Number:	1
Page Range:	67 - 70
DOI or Unique Handle:	10.1097/00007890-199101000-00010
Institution:	University of Pittsburgh
Refereed:	Yes
ISSN:	0041-1337
Other ID:	uls-drl:31735062117050, Starzl CV No. 1152
Date Deposited:	08 Apr 2010 17:19
Last Modified:	02 Aug 2020 10:57
URI:	http://d-scholarship.pitt.edu/id/eprint/4538

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