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Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections

Francavilla, A and Panella, C and Polimeno, L and Giangaspero, A and Mazzaferro, V and Pan, C and Van Thiel, DH and Starzl, TE (1990) Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. Hepatology, 12 (5). 1134 - 1138. ISSN 0270-9139

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Abstract

Thirteen patients who underwent 40% to 80% removal of their livers had blood samples drawn initially and daily on postoperative days 1 to 7. The enzyme marker of heightened polyamine metabolism, ornithine decarboxylase, and the indicator of DNA synthesis, thymidine kinase, were measured. In addition, the hormones (insulin, glucagon, estradiol and androgen), which in animals are known to reflect and possibly modulate regeneration, were measured. Changes in all these indices followed the same pattern as in rats, dogs and swine but at a slower rate. Ornithine decarboxylase and estradiol increased within 24 hr, but thymidine kinase and insulin rises did not become statistically significant until 3 to 5 days. Using these plasma or serum indices as surrogate measures of biochemical events in the liver itself, regeneration reached a maximum after 4 or 5 days. By computed tomography scan analysis, restoration of hepatic cell mass was not complete until 3 wk. (HEPATOLOGY 1990;12:1134–1138). Copyright © 1990 American Association for the Study of Liver Diseases


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Panella, C
Polimeno, L
Giangaspero, A
Mazzaferro, V
Pan, C
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 12
Number: 5
Page Range: 1134 - 1138
DOI or Unique Handle: 10.1002/hep.1840120510
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062117076, Starzl CV No. 1154
Date Deposited: 08 Apr 2010 17:19
Last Modified: 13 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/4540

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