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Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics.

Starzl, TE and Abu-Elmagd, K and Tzakis, A and Fung, JJ and Porter, KA and Todo, S (1991) Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics. Transplant Proc, 23 (1 Pt 2). 914 - 919. ISSN 0041-1345

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Abstract

FK 506 is a superior immunosuppressive agent that should improve the grafting of organs that already are part of our every day transplant practices, as well as those which are presently impractical. Immune intervention for serious autoimmune diseases also should be a more attractive option with this drug. Lessons are still being learned about dosage and what determines safe dose schedules. At a basic level, the study of FK 506 and its comparison to CyA may have shed light on mechanisms and characteristics of the whole class of so-called macrolide immunosuppresants and their cytosolic binding sites.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Abu-Elmagd, K
Tzakis, A
Fung, JJ
Porter, KA
Todo, S
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1991
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 23
Number: 1 Pt 2
Page Range: 914 - 919
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Amino Acid Isomerases, Animals, Anti-Bacterial Agents, Carrier Proteins, Humans, Immunosuppression, Immunosuppressive Agents, Liver Regeneration, Organ Transplantation, Peptidylprolyl Isomerase, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (DK 29961)
Other ID: uls-drl:31735062117118, Starzl CV No. 1159
Date Deposited: 08 Apr 2010 17:19
Last Modified: 05 Dec 2017 16:59
URI: http://d-scholarship.pitt.edu/id/eprint/4545

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