Zhang, Yuyu
(2024)
Molecular Modulator Approach for Controlling the Length of Chiral 1D Single-Helical Gold Nanoparticle Superstructures.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Peptide-based methods have proven useful for constructing helical gold nanoparticle
superstructures that exhibit strong plasmonic chiroptical activity. Superstructure syntheses using
the amphiphilic peptide conjugate C16-(AYSSGAPPMoxPPF)2 typically yield 1D helices with a
broad length distribution. In this study, we introduce a molecular modulator approach for
controlling helix length. It represents a first step toward achieving narrowly disperse populations
of single helices fabricated using peptide-based methods. Varying amounts of modulator, C16
(AYSSGA)2, were added to C16-(AYSSGAPPMoxPPF)2-based single-helix syntheses, resulting in
decreased helix length and narrowing of the helix length distribution. Kinetic studies of fiber
assembly were performed to investigate the mechanism by which the modulator affects helix
length. It was found that the modulator leads to rapid peptide conjugate nucleation and fiber
growth, which in turn results in large amounts of short fibers that serve as the underlying scaffold
for the single-helix superstructures. These results constitute important advances toward generating
monodisperse samples of plasmonic helical colloids.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
9 January 2024 |
| Date Type: |
Publication |
| Defense Date: |
9 June 2022 |
| Approval Date: |
9 January 2024 |
| Submission Date: |
30 October 2023 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
70 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Fibers, Gold nanoparticle superstructure, modulators, peptides and proteins |
| Date Deposited: |
09 Jan 2024 19:28 |
| Last Modified: |
09 Jan 2024 19:28 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/45477 |
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