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Molecular Modulator Approach for Controlling the Length of Chiral 1D Single-Helical Gold Nanoparticle Superstructures

Zhang, Yuyu (2024) Molecular Modulator Approach for Controlling the Length of Chiral 1D Single-Helical Gold Nanoparticle Superstructures. Master's Thesis, University of Pittsburgh. (Unpublished)

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Peptide-based methods have proven useful for constructing helical gold nanoparticle
superstructures that exhibit strong plasmonic chiroptical activity. Superstructure syntheses using
the amphiphilic peptide conjugate C16-(AYSSGAPPMoxPPF)2 typically yield 1D helices with a
broad length distribution. In this study, we introduce a molecular modulator approach for
controlling helix length. It represents a first step toward achieving narrowly disperse populations
of single helices fabricated using peptide-based methods. Varying amounts of modulator, C16
(AYSSGA)2, were added to C16-(AYSSGAPPMoxPPF)2-based single-helix syntheses, resulting in
decreased helix length and narrowing of the helix length distribution. Kinetic studies of fiber
assembly were performed to investigate the mechanism by which the modulator affects helix
length. It was found that the modulator leads to rapid peptide conjugate nucleation and fiber
growth, which in turn results in large amounts of short fibers that serve as the underlying scaffold
for the single-helix superstructures. These results constitute important advances toward generating
monodisperse samples of plasmonic helical colloids.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Zhang, Yuyuyuz193@pitt.eduyuz193
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairRosi, Nathaniel
Committee MemberMillstone,
Committee MemberChilders,
Date: 9 January 2024
Date Type: Publication
Defense Date: 9 June 2022
Approval Date: 9 January 2024
Submission Date: 30 October 2023
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 70
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Fibers, Gold nanoparticle superstructure, modulators, peptides and proteins
Date Deposited: 09 Jan 2024 19:28
Last Modified: 09 Jan 2024 19:28


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