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FK 506 prevents spontaneous diabetes in the BB rat.

Murase, N and Lieberman, I and Nalesnik, M and Mintz, D and Todo, S and Drash, AL and Starzl, TE (1991) FK 506 prevents spontaneous diabetes in the BB rat. Transplant Proc, 23 (1 Pt 1). 551 - 555. ISSN 0041-1345

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The BB rat is the experimental analogue of human juvenile diabetes mellitus. From 30 through 120 days after birth, 59 BB rats were treated with water (n = 20), or FK 506 in daily intragastric doses of 1 mg/kg (n = 19) or 2 mg/kg (n = 20). Diabetes developed in 75%, 15%, and 0% of the three groups. Animals protected from diabetes by FK 506, and killed in the nondiabetic state at 120 days had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, normal pancreatic insulin content, and immunocytochemical confirmation of islet insulin and glucagon content. Forty five to 75 days after stopping FK 506, about 3/4 of the animals who were diabetes free at 120 days have remained so. These results provide support for a clinical trial of FK 506 for recent onset diabetes.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Murase, N
Lieberman, I
Nalesnik, M
Mintz, D
Todo, S
Drash, AL
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1991
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 23
Number: 1 Pt 1
Page Range: 551 - 555
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Animals, Anti-Bacterial Agents, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Female, Glucose Tolerance Test, Immunosuppressive Agents, Insulin, Islets of Langerhans, Male, Rats, Rats, Inbred BB, Rats, Inbred WF, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19), NIDDK NIH HHS (DK 29961)
Other ID: uls-drl:31735062117225, Starzl CV No. 1170
Date Deposited: 08 Apr 2010 17:20
Last Modified: 13 Oct 2017 21:58


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