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One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.


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Todo, S and Fung, JJ and Tzakis, A and Demetris, AJ and Jain, A and Alessiani, M and Takaya, S and Day, R and Gordon, R and Starzl, TE (1991) One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults. Transplant Proc, 23 (1 Pt 2). 1397 - 1402. ISSN 0041-1345

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An account is given of the 6- to 12-month survival, and causes of failure in 110 consecutive patients who underwent primary liver transplantation under treatment from the outset with FK 506 and steroids. The patient survival is 92.7%, and the first graft survival is 87.3%. At a very high frequency, the patients achieved good graft function, and they had a relatively low morbidity that was partially ascribable to minimal use and early discontinuance (in 60% of cases) of steroids. Renal dysfunction and other adverse findings were largely confined to patients with poor initial graft function and consequent apparent alteration of the kinetics of FK 506 elimination, causing functional overdosage. Results compare very favorably with our past record using conventional immunosuppression, and support the belief that FK 506 is a superior immunosuppressive agent which is suitable for chronic administration.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Fung, JJ
Tzakis, A
Demetris, AJ
Jain, A
Alessiani, M
Takaya, S
Day, R
Gordon, R
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1991
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 23
Number: 1 Pt 2
Page Range: 1397 - 1402
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adult, Alanine Transaminase, Anti-Bacterial Agents, Aspartate Aminotransferases, Bilirubin, Blood Urea Nitrogen, Cause of Death, Cholesterol, Creatine, Cyclosporins, Graft Survival, Humans, Hypertension, Immunosuppression Therapy, Immunosuppressive Agents, Jaundice, Kidney, Liver Transplantation, Prednisone, Survival Analysis, Tacrolimus, Uric Acid, gamma-Glutamyltransferase
ISSN: 0041-1345
Funders: PHS HHS (29961)
Other ID: uls-drl:31735062117282, Starzl CV No. 1176
Date Deposited: 08 Apr 2010 17:20
Last Modified: 18 Dec 2021 13:55


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