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Examining the relationships between psychosocial stress exposure, glucocorticoid resistance in immune cells and cardiometabolic risk

Eckerle, William (2024) Examining the relationships between psychosocial stress exposure, glucocorticoid resistance in immune cells and cardiometabolic risk. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

The present study examined the relationships between chronic stress, glucocorticoid resistance in immune cells and cardiometabolic risk factors. 247 adults completed measures of psychological stress and underwent a blood draw and anthropometric assessment. Glucocorticoid resistance was measured as the concentration of dexamethasone required to reduce IL-6 concentration in half after mitogen exposure, and cardiometabolic risk consisted of a composite score of blood pressure, triglycerides, glucose scores, HDL, and waist circumference. Linear regression analyses revealed largely null results. Stress was not found to be associated with glucocorticoid resistance or cardiometabolic risk across 3 of 4 measures of psychological stress. A small, negative association between a novel measure of chronic stress and glucocorticoid resistance was observed. Results suggest need for further research into the conditions under which stress alters immune and cardiometabolic functioning.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Eckerle, Williamwde4@pitt.eduwde40000-0001-7380-4905
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairKamarck, Thomastkam@pitt.edu
Committee MemberMarsland, Annamarsland@pitt.edu
Committee MemberReed, Rebeccargr19@pitt.edu
Date: 10 January 2024
Date Type: Publication
Defense Date: 12 October 2023
Approval Date: 10 January 2024
Submission Date: 11 November 2023
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 56
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: stress, glucocorticoids, cardiometabolic risk, glucocorticoid resistance
Date Deposited: 10 Jan 2024 14:14
Last Modified: 10 Jan 2024 14:14
URI: http://d-scholarship.pitt.edu/id/eprint/45646

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