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The question of FK 506 nephrotoxicity after liver transplantation.

McCauley, J and Takaya, S and Fung, J and Tzakis, A and Abu-Elmagd, K and Jain, A and Todo, S and Starzl, TE (1991) The question of FK 506 nephrotoxicity after liver transplantation. Transplant Proc, 23 (1 Pt 2). 1444 - 1447. ISSN 0041-1345

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Abstract

Formal studies have not been published on the nephrotoxicity of FK 506 when the drug was used from the outset. This kind of information was sought in 101 recipients of primary livers, 24 hearts, and 3 double lungs or heart-lung. Perioperative renal dysfunction was commonly seen, which appeared to be related to FK 506 doses and plasma levels, particularly when the drug was given IV. This was reversible. Late renal function has been generally satisfactory in all three cohorts of patients, and the incidence of hypertension has been low. The therapeutic index of FK 506 is a good one, as revealed by these observations in patients whose most notable achievement was a low mortality.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
McCauley, J
Takaya, S
Fung, J
Tzakis, A
Abu-Elmagd, K
Jain, A
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1991
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 23
Number: 1 Pt 2
Page Range: 1444 - 1447
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Anti-Bacterial Agents, Creatinine, Dose-Response Relationship, Drug, Heart Transplantation, Heart-Lung Transplantation, Humans, Immunosuppression, Immunosuppressive Agents, Kidney Diseases, Liver Transplantation, Lung Transplantation, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19), PHS HHS (29961)
Other ID: uls-drl:31735062117365, Starzl CV No. 1184
Date Deposited: 08 Apr 2010 17:20
Last Modified: 13 Oct 2017 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/4570

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