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Orthotopic liver transplantation for patients with hepatitis B virus–related liver disease

Todo, S and Demetris, AJ and van Thiel, D and Teperman, L and Fung, JJ and Starzl, TE (1991) Orthotopic liver transplantation for patients with hepatitis B virus–related liver disease. Hepatology, 13 (4). 619 - 626. ISSN 0270-9139

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Fifty‐nine patients with prior hepatitis B virus infection underwent orthotopic liver transplantation. During the first 2 mo, mortality was not significantly different in the hepatitis B virus–infected group (25.5%) vs. a hepatitis B virus–immune control group (21%). Beyond 2 mo, the mortality, rate of graft loss, need for retransplantation and incidence of abnormal liver function were significantly higher in the hepatitis B virus–infected group. Treatment of the hepatitis B virus infection was attempted with passive immunization, combined active and passive immunization, α‐interferon or nothing. The clinical outcome was not significantly influenced by any of these therapies. However, of the patients who lived more than 60 days, 6 of 22 treated with active plus passive immunization were cleared of HBsAg, something achieved once in 16 patients treated with α‐interferon, never in 3 patients with passive immunization only and once in 4 patients with no therapy. In patients with recurrent hepatitis B virus infection, the pace of hepatitis development in the graft appeared to be accelerated, and this was particularly striking in patients who underwent multiple retransplantations at progressively shorter intervals. None of the patients who became HBsAg‐negative had HBeAg preoperatively. (HEPATOLOGY 1991;13:619–626.) Copyright © 1991 American Association for the Study of Liver Diseases


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Demetris, AJ
van Thiel, D
Teperman, L
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 13
Number: 4
Page Range: 619 - 626
DOI or Unique Handle: 10.1002/hep.1840130402
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062117423, Starzl CV No. 1190
Date Deposited: 08 Apr 2010 17:20
Last Modified: 27 Jan 2019 02:55


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