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Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with uw solution

Furukawa, H and Todo, S and Imventarza, O and Casavilla, A and Wu, YM and Scotti-Foglieni, C and Broznick, B and Bryant, J and Day, R (1991) Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with uw solution. Transplantation, 51 (5). 1000 - 1004. ISSN 0041-1337

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Abstract

Five hundred ninety-three cadaveric livers were used for primary liver transplantation between October 24, 1987, and May 19, 1989. The grafts were procured with a combined method, using in situ cooling with cold electrolyte solution and backtable flushing with UW solution. The mean cold-ischemia time was 12.8 (range 2.4- 34.7) hr. The cases were divided into 5 groups according to the cold-ischemia time: Group 1: < 10 hr (n=223); group 2:10-14 hr (n=188); group 3:15-19 hr (n=101); group 4: 20-24 hr (n=52); and group 5: > 25 hr (n=29). There was no difference between the 5 groups in 1-year patient survival, highest SGOT in first week after operation, and SGOT and total bilirubin during the first month after operation. However, with a logistic regression model, the retransplantation rate (P=0.001) and primary nonfunction rate (P=0.006) significantly rose as cold-ischemia time increased, meaning that the equivalency of patient survival was increasingly dependent on aggressive retransplantation. © 1991 by Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Furukawa, H
Todo, S
Imventarza, O
Casavilla, A
Wu, YM
Scotti-Foglieni, C
Broznick, B
Bryant, J
Day, R
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 51
Number: 5
Page Range: 1000 - 1004
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062117464, Starzl CV No. 1194
Date Deposited: 08 Apr 2010 17:20
Last Modified: 13 Oct 2017 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/4580

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