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Aspergillosis of the CNS in a pediatric liver transplant recipient: Case report and review

Green, M and Wald, ER and Tzakis, A and Todo, S and Starzl, TE (1991) Aspergillosis of the CNS in a pediatric liver transplant recipient: Case report and review. Reviews of Infectious Diseases, 13 (4). 653 - 657. ISSN 0162-0886

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Abstract

A 2-month-old infant who had undergone orthotopic liver transplantation at the age of 2 weeks for carbamoyl phosphate synthetase deficiency developed infection of the CNS due to Aspergillus fumigatus. The patient was successfully treated with administration of a combination of antifungal agents (including intraventricular amphotericin B), drainage of the parietal lobe abscess, and cessation of immunosuppression. An intraventricular catheter was used both to obtain ventricular fluid for microbiologic testing and to deliver amphotericin B during nearly 4 months of treatment. We review literature on aspergillosis in solid-organ transplant recipients, especially those in whom the disease involves the CNS, and discuss in particular clinical presentation, diagnosis, treatment, and outcome.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Green, M
Wald, ER
Tzakis, A
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Reviews of Infectious Diseases
Volume: 13
Number: 4
Page Range: 653 - 657
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0162-0886
Other ID: uls-drl:31735062117530, Starzl CV No. 1201
Date Deposited: 08 Apr 2010 17:20
Last Modified: 12 Oct 2017 08:57
URI: http://d-scholarship.pitt.edu/id/eprint/4587

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