Markus, PM and Cai, X and Ming, W and Demetris, AJ and Fung, JJ and Starzl, TE
(1991)
FK 506 reverses acute graft-versus-host disease after allogeneic bone marrow transplantation in rats.
Surgery, 110 (2).
357 - 364.
ISSN 0039-6060
Abstract
Severe graft-versus-host disease was induced by transplantation of ACI rat bone marrow and spleen cells into irradiated Lewis rat recipients. Treatment with FK 506 or cyclosporine A (CsA) was started after clinical and histologic evidence of acute GVHD was present. A 14-day course of FK 506 at 1.0 mg/kg/day could rescue 100% of the animals suffering from GVHD. In contrast only one half of the animals treated with CsA at a high dose of 25 mg/kg/day recovered. After cessation of immunosuppressive therapy, FK 506-treated animals displayed a marked prolonged disease-free interval as compared to CsA-treated bone marrow recipients. Recurrence of the disease in these animals could be prevented when FK 506 treatment was continued after the induction period with a low maintenance dose of 0.1 mg/kg/day every other day.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Markus, PM | | | | | Cai, X | | | | | Ming, W | | | | | Demetris, AJ | | | | | Fung, JJ | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 December 1991 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Surgery |
| Volume: |
110 |
| Number: |
2 |
| Page Range: |
357 - 364 |
| Event Type: |
Conference |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0039-6060 |
| Other ID: |
uls-drl:31735062117571, Starzl CV No. 1206 |
| Date Deposited: |
08 Apr 2010 17:20 |
| Last Modified: |
05 Feb 2019 16:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4592 |
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