FK 506 reverses acute graft-versus-host disease after allogeneic bone marrow transplantation in rats

Markus, PM and Cai, X and Ming, W and Demetris, AJ and Fung, JJ and Starzl, TE (1991) FK 506 reverses acute graft-versus-host disease after allogeneic bone marrow transplantation in rats. Surgery, 110 (2). 357 - 364. ISSN 0039-6060

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Abstract

Severe graft-versus-host disease was induced by transplantation of ACI rat bone marrow and spleen cells into irradiated Lewis rat recipients. Treatment with FK 506 or cyclosporine A (CsA) was started after clinical and histologic evidence of acute GVHD was present. A 14-day course of FK 506 at 1.0 mg/kg/day could rescue 100% of the animals suffering from GVHD. In contrast only one half of the animals treated with CsA at a high dose of 25 mg/kg/day recovered. After cessation of immunosuppressive therapy, FK 506-treated animals displayed a marked prolonged disease-free interval as compared to CsA-treated bone marrow recipients. Recurrence of the disease in these animals could be prevented when FK 506 treatment was continued after the induction period with a low maintenance dose of 0.1 mg/kg/day every other day.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Markus, PM Cai, X Ming, W Demetris, AJ Fung, JJ Starzl, TE tes11@pitt.edu TES11
Centers:	Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date:	1 December 1991
Date Type:	Publication
Journal or Publication Title:	Surgery
Volume:	110
Number:	2
Page Range:	357 - 364
Event Type:	Conference
Institution:	University of Pittsburgh
Refereed:	Yes
ISSN:	0039-6060
Other ID:	uls-drl:31735062117571, Starzl CV No. 1206
Date Deposited:	08 Apr 2010 17:20
Last Modified:	05 Feb 2019 16:55
URI:	http://d-scholarship.pitt.edu/id/eprint/4592

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