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In vivo effect of FK506 on human pancreatic islets

Ricordi, C and Zeng, Y and Alejandro, R and Tzakis, A and Venkataramanan, R and Fung, J and Bereiter, D and Mintz, DH and Starzl, TE (1991) In vivo effect of FK506 on human pancreatic islets. Transplantation, 52 (3). 519 - 522. ISSN 0041-1337

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Abstract

The purpose of this study was to evaluate the in vivo effect of FK506 on human pancreatic islets. Twenty-five nude mice were made diabetic by one intravenous injection of streptozotocin. Approximately 600 islets were administered in the renal subcapsular space 3-5 days following streptozotocin administration. One week after transplantation, the mice were divided in four groups. In group 1, the animals received 1 injection of 0.5 ml of diluent i.p. daily for one week. In groups 2, 3, and 4 the treatments were daily i.p. injection of 0.3, 1, and 3 mg/kg FK506, respectively. After treatment, the functional integrity of the transplanted human islets was tested by measuring the plasma glucose and human C-peptide response to intraperitoneal glucose injection in groups 1 and 4. IPGTT alone was assessed in groups 2 and 3. The results indicate that i.p. administration of FK506 for one week at a dose 0.3 mg/kg/day did not result in any significant alteration of glucose disappearance and C-peptide response to IPGTT. Higher doses of FK506 produced a significant delay in glucose disappearance in groups 3 and 4, and a significant inhibition of glucose-mediated C-peptide response in group 4. © 1991 by Williams and Wilkins.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ricordi, C
Zeng, Y
Alejandro, R
Tzakis, A
Venkataramanan, Rrv@pitt.eduRV
Fung, J
Bereiter, D
Mintz, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 52
Number: 3
Page Range: 519 - 522
DOI or Unique Handle: 10.1097/00007890-199109000-00026
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062117613, Starzl CV No. 1210
Date Deposited: 08 Apr 2010 17:20
Last Modified: 02 Aug 2020 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/4596

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