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Overview of FK506 in transplantation.

Fung, JJ and Abu-Elmagd, K and Todo, S and Shapiro, R and Tzakis, A and Jordan, M and Armitage, J and Jain, A and Alessiani, M and Martin, M (1990) Overview of FK506 in transplantation. Clinical transplants. 115 - 121. ISSN 0890-9016

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FK506 is a potent immunosuppressive agent which is undergoing clinical testing in liver, kidney, heart, and bone marrow transplantation. It has been shown to effectively prevent and reverse ongoing rejection in these models. From the outset, FK506 was used with low-dose steroids to treat 110 primary liver, 30 heart, and 66 kidney graft recipients. FK506 was also used in the setting of complications related to CsA or to ongoing chronic or acute rejection. One hundred seventy-three liver, 21 kidney, 10 heart, and 11 bone marrow recipients were converted to FK506 and low-dose steroids, from a combination of CsA, steroids, and/or Aza. A randomized, prospective trial comparing FK506 with CsA in primary liver transplantation has verified the lower incidence of rejection and greater ease in treating rejection episodes, with fewer adverse effects. In summary, FK506 has proven to be an effective baseline immunosuppressive agent, as well as a dose-adjustable agent for the treatment of rejection.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Fung, JJ
Abu-Elmagd, K
Todo, S
Shapiro, R
Tzakis, A
Jordan, M
Armitage, J
Jain, A
Alessiani, M
Martin, M
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Clinical transplants
Page Range: 115 - 121
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0890-9016
Other ID: uls-drl:31735062117712, Starzl CV No. 1220
PubMed ID: 1715740
Date Deposited: 08 Apr 2010 17:20
Last Modified: 12 Feb 2019 15:55


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