Sekel, Nicole
(2024)
The Role of Physiologic Loading, Micronutrient and Trace Mineral Deficiencies and Senescence on Bone Functional Adaptation.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
Bone functional adaptation refers to bone tissue’s ability to optimize its structure and mass through adaptive processes, ultimately meeting the contradictory needs of stiffness and flexibility with sufficient stiffness lending to resistance to deformation (i.e. strain) and flexibility that allows for storage of energy in elastic (i.e. reversable) deformation during impact loading, muscle contraction and joint movement. Emerging evidence supports the integral role of micronutrients—namely vitamin D and iron—in mediating bone homeostasis through different mechanisms at the composition, tissue-level and morphologic level. While prior imaging modalities have lacked the resolution necessary to discern evidence of an adaptive response, the pQCT and focally, the HR-pQCT have provided researchers the ability to investigate bone microarchitecture in vivo and quantify densitometric, morphological and geometric adaptation in response to exercise and training exposure, such as concurrent resistance training or military training. Conversely, in an ageing population, the full consequence of micronutrient deficiency and cellular senescence on bone quality remains unknown due to the over reliance of osteoporosis research on low-resolution imaging modalities and the disproportional recruitment of women in prior studies. Therefore, the purpose of this work is to examine the synergistic effort of combining varying physiologic loading models (concurrent resistance training, military training) with potential mediating factors of bone functional adaptation including sex-specific responses, non-mechanical factors such as nutritional deficiencies and cellular senescence in order to further elucidate characteristics contributing to bone functional adaptation.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
6 June 2024 |
| Date Type: |
Publication |
| Defense Date: |
12 March 2024 |
| Approval Date: |
6 June 2024 |
| Submission Date: |
16 April 2024 |
| Access Restriction: |
2 year -- Restrict access to University of Pittsburgh for a period of 2 years. |
| Number of Pages: |
184 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Health and Rehabilitation Sciences > Sports Medicine and Nutrition |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
HR-pQCT, military, older men, micronutrient status, vitamin D, iron |
| Date Deposited: |
06 Jun 2024 14:00 |
| Last Modified: |
06 Jun 2024 14:00 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/46129 |
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