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The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders: An in situ hybridization study

Randhawa, PS and Jaffe, R and Demetris, AJ and Nalesnik, M and Starzl, TE and Chen, YY and Weiss, LM (1991) The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders: An in situ hybridization study. American Journal of Pathology, 138 (4). 1027 - 1033. ISSN 0002-9440

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Abstract

The systemic distribution of Epstein-Barr virus (EBV) genomes was studied in paraffin-embedded tissues from 12 fatal cases of Post-transplantation lymphoproliferative disease (PTLD), using an in situ hybridization technique employing an alpha- 35 S-dCTP-radiolabeled BamHI-W fragment of EBV DNA. The presence of EBV was documented in various PTLD-involved organs. The hybridization signal for the virus localized predominantly in the abnormal lymphoid cells, but signals also were detected in hepatocytes and/or adrenal cortical cells in five cases. The distribution of autoradiographic label within the lymphoid cells was focal and its intensity varied from field to field, suggesting a nonuniformity of the viral genomic load in the infected tissues. Recruitment of EBV genome-bearing cells was not observed into inflammatory mononuclear infiltrates found in organs without histopathologic evidence of PTLD.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Randhawa, PS
Jaffe, R
Demetris, AJ
Nalesnik, M
Starzl, TEtes11@pitt.eduTES11
Chen, YY
Weiss, LM
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: American Journal of Pathology
Volume: 138
Number: 4
Page Range: 1027 - 1033
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-9440
Other ID: uls-drl:31735062117811, Starzl CV No. 1230
Date Deposited: 08 Apr 2010 17:21
Last Modified: 14 Nov 2017 01:55
URI: http://d-scholarship.pitt.edu/id/eprint/4616

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