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In‐vitro Interaction of a Novel Immunosuppressant, FK 506, and Antacids

STEEVES, M and ABDALLAH, HY and VENKATARAMANAN, R and BURCKART, GJ and PTACHCINSKI, RJ and ABU‐ELMAGD, K and JAIN, AK and FUNG, F and TODO, S and STARZL, TE (1991) In‐vitro Interaction of a Novel Immunosuppressant, FK 506, and Antacids. Journal of Pharmacy and Pharmacology, 43 (8). 574 - 577. ISSN 0022-3573

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Abstract

Abstract— The effect of selected antacids on the amount of FK 506 in solution in simulated gastric juice has been studied. FK 506 (2–5 mg) was incubated in 100 mL simulated gastric fluid (SGF) with the equivalent of 500 mg of various antacids. The addition of Mylanta and Turns resulted in 14 and 30% loss of FK 506, respectively, in 24 h; 98% loss was observed in 12 h in the presence of Mag‐Ox; 100% loss was observed in the presence of magnesium oxide powder in 2 h. The loss of FK 506 from these solutions appears to be due to a pH mediated degradation of FK 506. The addition of aluminium hydroxide gel USP (Roxane) to the FK 506 solution resulted in a 35% loss within 2 min but no further loss was noted for 24 h, indicative of adsorption of FK 506. These results suggest that until additional in‐vivo studies are carried out, it is prudent not to dose FK 506 and antacids at the same time to avoid potential interactions. 1991 Royal Pharmaceutical Society of Great Britain

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
STEEVES, M
ABDALLAH, HY
VENKATARAMANAN, Rrv@pitt.eduRV
BURCKART, GJ
PTACHCINSKI, RJ
ABU‐ELMAGD, K
JAIN, AK
FUNG, F
TODO, S
STARZL, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Journal of Pharmacy and Pharmacology
Volume: 43
Number: 8
Page Range: 574 - 577
DOI or Unique Handle: 10.1111/j.2042-7158.1991.tb03539.x
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-3573
Other ID: uls-drl:, Starzl CV No. 1232
PubMed ID: 1717676
Date Deposited: 08 Apr 2010 17:21
Last Modified: 02 Aug 2020 10:57
URI: http://d-scholarship.pitt.edu/id/eprint/4618

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