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The Association Between Oral and Systemic Conditions using the Staging and Grading Diagnosis of Periodontitis

karrotu, lavanya (2024) The Association Between Oral and Systemic Conditions using the Staging and Grading Diagnosis of Periodontitis. Master's Thesis, University of Pittsburgh. (Unpublished)

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Several studies have suggested an association between oral infection, especially periodontitis with systemic diseases due to the release of inflammatory mediators like C-reactive protein (CRP), tumor necrosis factor (TNF), interleukin 1 and 6, prostaglandins E2 (PGE2) and matrix metalloproteinases (MMP). Periodontitis is a multifactorial inflammatory condition and one of the most common diseases in the oral cavity. Previous studies have shown the associations between periodontitis and different systemic conditions. However, most of the studies exploring the association between periodontal health and overall health were conducted using the 1999 American Academy of Periodontology (AAP) classification. In 2017 the American Association of Periodontology and the European Federation of Periodontology (EEP) created a new classification for periodontitis diagnosis which includes the rate of progression and the inclusion of diabetes and smoking status as modifying factors influencing the diagnosis. Guided by the available literature and by identified gaps related to the association between systemic and oral health, our research focused on determining the associations between the new staging and grading diagnosis of periodontitis created by the AAP/EEP in 2017 and systemic diseases. We leveraged a cohort of research participants recruited as part of the Dental Registry and DNA Repository (DRDR) at the University of Pittsburgh, School of Dental Medicine to conduct epidemiologic and candidate gene analyses to identify these associations with the most common comorbidities reported at the DRDR. Our study design consists of association studies, including phenotypic and genotypic analysis. We also aimed
to determine if a genetic variant that has been found to overlap between periodontitis and conditions such as cardiovascular disease and cancers (rs1333048 in ANRIL) is associated with highly characterized oral infection phenotypes in a population from Pittsburgh undergoing regular dental treatment. We have selected a cohort from the (DRDR) and defined the diagnosis of periodontitis according to stages and grades, using the updated criteria. We found a potential link between periodontitis stages 3 and 4, cancer, and asthma. In addition to that, we found an association between the rs1333048 in ANRIL in participants with periodontitis in stages 3 and 4.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
karrotu, lavanyalak208@pitt.edulak208
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Bezamat, Marianambl29@pitt.edumbl29
Verdelis, Konstantinoskv100@pitt.edukv100
Clark, Danieldrc109@pitt.edudrc109
Date: 13 May 2024
Date Type: Publication
Defense Date: 27 March 2024
Approval Date: 13 May 2024
Submission Date: 18 April 2024
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 65
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: ANRIL, DRDR, Periodontitis, SNPrs1333048
Date Deposited: 13 May 2024 12:35
Last Modified: 13 May 2024 12:35


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