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Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation

Yokoyama, I and Carr, B and Saitsu, H and Iwatsuki, S and Starzl, TE (1991) Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation. Cancer, 68 (10). 2095 - 2100. ISSN 0008-543X

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The growth rates of recurrent hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLTX) were estimated by calculating the tumor doubling time (TDT) in 20 patients. The mean TDT, calculated by multiple measurement of tumor size, was 44.3 ± 11.3 days (mean ± standard error) in 12 patients with pulmonary metastasis (range, 10 to 161 days) and 37.6 ± 8.9 days (range, 7 to 65 days) in 5 patients with liver allograft recurrence. The TDT as estimated by serum alpha‐fetoprotein (AFP) levels in 6 patients was 37.3 ± 10.0 days (range, 12 to 84 days). The mean TDT obtained from 5 control subjects with HCC who were treated with liver resection (without immunosuppression) was 273.8 ± 79.1 days (range, 82 to 560 days). The disease‐free period and survival time after OLTX both correlated well with the TDT (r = 0.546 and r = 0.701, respectively). The patients with fibrolamellar HCC had a greater TDT and a longer survival time than those with nonfibrolamellar HCC. Despite a wide range of TDT in patients who received transplants, their recurrent HCC tumors grew significantly faster than those of patients with the same disease who did not receive transplants. The factors involved in this accelerated growth rate may include the use of immunosuppressive drugs and the consequent suppression of host immunity against the growth of micrometastasis. Cancer 68:2095–2100. Copyright © 1991 American Cancer Society


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Yokoyama, I
Carr, B
Saitsu, H
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Cancer
Volume: 68
Number: 10
Page Range: 2095 - 2100
DOI or Unique Handle: 10.1002/1097-0142(19911115)68:10<2095::aid-cncr2820681002>;2-y
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0008-543X
Other ID: uls-drl:31735062117951, Starzl CV No. 1244
Date Deposited: 08 Apr 2010 17:21
Last Modified: 02 Feb 2019 13:55


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