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A Systematic Review of Large Particle Aerosol Generation and its Effects on the Clinical Manifestation of Pathogens

Katyal, Christopher (2024) A Systematic Review of Large Particle Aerosol Generation and its Effects on the Clinical Manifestation of Pathogens. Master Essay, University of Pittsburgh.

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Large particle aerosol generation is defined as the generation of particles that are at least 10 μm in diameter. Large particle aerosol generation can be used in many kinds of research. Perhaps the most important aspect of aerosol research is in biodefense. Understanding the impact of particle size on subsequent infection and disease can lead to important insights into disease progression as well as potential vaccine and therapeutics. There are a variety of aerosol generators that specialize in making different sizes of particles as well as ways to measure the size of aerosol particles. Studies into large particle generation as it pertains to disease progression and severity have generally shown that infection via large particle aerosol typically results in that pathogen becoming less infective and less severe. This is likely due to the pattern of deposition in the respiratory tract that is observed based on particle size. Large particles tend to deposit in the upper respiratory tract whereas small particles tend to deposit in the deep lung. This review aims to emphasize the link between particle size and disease severity and go over the different aerosol generators and models for large particle generation.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Katyal, Christopherchk133@pitt.educhk133
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairReed, Douglas S.dsreed@pitt.edudsreedUNSPECIFIED
Committee MemberGivens, David L.dlg43@pitt.edudlg43UNSPECIFIED
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 13 May 2024
Date Type: Completion
Number of Pages: 43
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 13 May 2024 18:31
Last Modified: 13 May 2024 18:31


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