Katyal, Christopher
(2024)
A Systematic Review of Large Particle Aerosol Generation and its Effects on the Clinical Manifestation of Pathogens.
Master Essay, University of Pittsburgh.
Abstract
Large particle aerosol generation is defined as the generation of particles that are at least 10 μm in diameter. Large particle aerosol generation can be used in many kinds of research. Perhaps the most important aspect of aerosol research is in biodefense. Understanding the impact of particle size on subsequent infection and disease can lead to important insights into disease progression as well as potential vaccine and therapeutics. There are a variety of aerosol generators that specialize in making different sizes of particles as well as ways to measure the size of aerosol particles. Studies into large particle generation as it pertains to disease progression and severity have generally shown that infection via large particle aerosol typically results in that pathogen becoming less infective and less severe. This is likely due to the pattern of deposition in the respiratory tract that is observed based on particle size. Large particles tend to deposit in the upper respiratory tract whereas small particles tend to deposit in the deep lung. This review aims to emphasize the link between particle size and disease severity and go over the different aerosol generators and models for large particle generation.
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