Schaeffer, Amanda, M.
(2024)
SARS-CoV-2 Pre-Exposure Prophylaxis - Examining Monoclonal Antibody Efficacy Among Immunocompromised Populations.
Master Essay, University of Pittsburgh.
Abstract
Vaccination against the novel SARS-CoV-2 virus was highly effective in the general population at protecting against infection, however for immunocompromised individuals the mRNA vaccines alone were not sufficient in providing an immune response to protect against the virus. The inadequate response to vaccination indicated the need for a pre-exposure prophylaxis agent to provide immunocompromised individuals an alternate form of passive immunity to the virus, further decreasing the risk of developing a severe response to the virus. Monoclonal antibodies (mAbs) were developed and tested for use as a prevention method, illustrating increased efficacy among immunocompromised populations where a sharp decrease in severe clinical adverse events (death, hospitalization) was noted amongst recipients. Given the severity of SARS-CoV-2 infection amongst immunocompromised patients, where the virus has a higher degree of severity and often a prolonged course of disease, there is an increased need to investigate current mAbs in terms of pre-exposure prophylaxis effectiveness and general efficacy of mAbs as prophylaxis are relatively new and many gaps in current literature exist. The importance of effective mAb pre-exposure prophylaxis for immunocompromised patients highlights the scope of Public Health objectives, specifically in aiding those who feel disease risk more strongly.
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Details
| Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID  |
|---|
| Committee Chair | Glynn, Nancy W. | epidnwg@pitt.edu | epidnwg | UNSPECIFIED | | Committee Member | Haidar, Ghady | haidarg@upmc.edu | UNSPECIFIED | UNSPECIFIED | | Committee Member | Fischer, Dawn | fiscde@upmc.edu | UNSPECIFIED | UNSPECIFIED |
|
| Date: |
21 May 2024 |
| Date Type: |
Completion |
| Submission Date: |
25 April 2024 |
| Access Restriction: |
2 year -- Restrict access to University of Pittsburgh for a period of 2 years. |
| Number of Pages: |
52 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Epidemiology |
| Degree: |
MPH - Master of Public Health |
| Thesis Type: |
Master Essay |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
SARS-CoV-2, COVID-19, Immunocompromised, Monoclonal Antibody Therapy, Pre-Exposure Prophylaxis, Prevention, Public Health |
| Date Deposited: |
21 May 2024 14:32 |
| Last Modified: |
21 May 2024 14:32 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/46305 |
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