Oliver, Dominika
(2024)
Modeling Community and Genomic Factors of HIV Susceptibility in the All of Us Research Program.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Objective: To investigate the association between genes in the region of 46 million base pairs (MBP) and 47MBP on chromosome 3, community factors, and HIV susceptibility using the All of Us research program.
Methods: 4100 individuals enrolled in the All of Us research program, 2050 healthy controls and 2050 HIV patients, were propensity score-matched on age, sex, and race. Community factors from subject resident ZIP codes at time of enrollment were modeled using logistic regression against HIV susceptibility for all 4100 subjects. Separately, 3227 individuals with available short read genomic information had separate logistic regression models run on 64 different genetic variants from the chromosome 3 region of interest to determine their association with HIV susceptibility alone and controlling for community factors found to be significant in the community-factors only model. Relationships were considered statistically significant with a Bonferroni-corrected p-value of 8.8099x10-5.
.Results: In the community-only model, race/ethnicity, percentage of individuals on assisted income, percentage of individuals with at least a high school education, and percentage of vacant housing were found to be significantly related to HIV susceptibility. In the genomics-only models, 24 genetic variants were found to be statistically significantly related to HIV susceptibility. After controlling for community factors, no genetic variants were found to be statistically significantly related to HIV susceptibility.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
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| ETD Committee: |
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| Date: |
14 May 2024 |
| Date Type: |
Publication |
| Defense Date: |
22 April 2024 |
| Approval Date: |
14 May 2024 |
| Submission Date: |
29 April 2024 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
47 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Biostatistics |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
HIV Susceptibility, CCR5, All of Us, Genomics |
| Date Deposited: |
14 May 2024 18:32 |
| Last Modified: |
14 May 2024 18:32 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/46356 |
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