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A comparison of the renal effects (ERPF, GFR, and FF) of FK 506 and cyclosporine in patients with liver transplantation

Tauxe, WN and Mochizuki, T and McCauley, J and Starzl, TE and Jain, A and Charron, M (1991) A comparison of the renal effects (ERPF, GFR, and FF) of FK 506 and cyclosporine in patients with liver transplantation. Transplantation Proceedings, 23 (6). 3146 - 3147. ISSN 0041-1345

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Abstract

1. The mean ''cost'' in milliliters per minute of ESLD alone, prior to transplantation, was 35% + 23% (1 SD). In GFR it was 15%. 2. The additional burden of CyA + OLT increases the loss in ERPF an additional 18%; in GFR, it increases loss another 10%. Thus, the total loss in CyA-treated patients was 53% and 25%, respectively. 3. The decrease imposed by FK 506 + OLT on ERPF was only 7%, with no decrease in GFR. 4. Therefore, from the renal point of view, FK 506 would appear to be the superior drug. 5. The large error around mean values underlines the desirability of performing these tests on the individual patient rather than on information from groups, since many values fall near the threshold of the azotemic range (ERPF approximately 175 mL/min). 6. As renal mass was compromised, ie, fall in the ERPF, the GFR increased relatively, ie, the renal filtering membrane became more permeable and the FFs gradually increased. 7. The loss of renal function was significantly less in OLT patients on FK 506 than CyA. However, the greatest loss in expected renal function was due to the basic ESLD itself.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tauxe, WN
Mochizuki, T
McCauley, J
Starzl, TEtes11@pitt.eduTES11
Jain, A
Charron, M
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 December 1991
Date Type: Publication
Journal or Publication Title: Transplantation Proceedings
Volume: 23
Number: 6
Page Range: 3146 - 3147
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1345
Other ID: uls-drl:31735062118553, Starzl CV No. 1302
Date Deposited: 08 Apr 2010 17:22
Last Modified: 02 Feb 2019 13:57
URI: http://d-scholarship.pitt.edu/id/eprint/4688

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