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The effect of bile duct ligation and bile diversion on FK506 pharmacokinetics in dogs

Furukawa, H and Imventarza, O and Venkataramanan, R and Suzuki, M and Zhu, Y and Warty, VS and Fung, J and Todo, S and Starzl, TE (1992) The effect of bile duct ligation and bile diversion on FK506 pharmacokinetics in dogs. Transplantation, 53 (4). 722 - 725. ISSN 0041-1337

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Abstract

Mongrel or beagle dogs were submitted to bile duct ligation, or to extraenteric biliary diversion by means of choledochoureterostomy. The kinetics of intravenously administered FK506 was not changed from control status two weeks after bile duct ligation, but the bioavailability of orally administered FK506 was nearly quadrupled. Following oral administration, the absorption of FK506 was highly variable. The results indicate that in dogs FK506 is absorbed from the intestine just as efficiently in the absence of enteric bile and in presence of exogenous bile salt supplement when compared with its absorption in presence of normal bile drainage. These findings with FK506 are different from those with cyclosporine after biliary obstruction or diversion and will have important practical as well as experimental ramifications. © 1992 by Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Furukawa, H
Imventarza, O
Venkataramanan, R
Suzuki, M
Zhu, Y
Warty, VS
Fung, J
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 53
Number: 4
Page Range: 722 - 725
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062118835, Starzl CV No. 1330
Date Deposited: 08 Apr 2010 17:22
Last Modified: 13 Oct 2017 21:55
URI: http://d-scholarship.pitt.edu/id/eprint/4716

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