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Cadaveric small bowel and small bowel-liver transplantation in humans

Todo, S and Tzakis, AG and Abu-Elmagd, K and Reyes, J and Fung, JJ and Casavilla, A and Nakamura, K and Yagihashi, A and Jain, A and Murase, N and Iwaki, Y and Demetris, AJ and Thiel, DV and Starzl, TE (1992) Cadaveric small bowel and small bowel-liver transplantation in humans. Transplantation, 53 (2). 369 - 376. ISSN 0041-1337

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Five patients had complete cadaveric small bowel transplants under FK506 immunosuppression, one as an isolated graft and the other 4 in continuity with a liver. Three were children and two were adults. The five patients are living 2-13 months posttransplantation with complete alimentation by the intestine. The typical postoperative course was stormy, with sluggish resumption of gastrointestinal function. The patient with small intestinal transplantation alone had the most difficult course of the five, including two severe rejections, bacterial and fungal translocation with bacteremia, renal failure with the rejections, and permanent consignment to renal dialysis. The first four patients (studies on the fifth were incomplete) had replacement of the lymphor-eticular cells in the graft lamina propria by their own lymphoreticular cells. Although the surgical and aftercare of these patients was difficult, the eventual uniform success suggests that intestinal transplantation has moved toward becoming a practical clinical service. © 1992 by Williams and Wilkins.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Tzakis, AG
Abu-Elmagd, K
Reyes, J
Fung, JJ
Casavilla, A
Nakamura, K
Yagihashi, A
Jain, A
Murase, N
Iwaki, Y
Demetris, AJ
Thiel, DV
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 53
Number: 2
Page Range: 369 - 376
DOI or Unique Handle: 10.1097/00007890-199202010-00020
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062111251, Starzl CV No. 1333
Date Deposited: 08 Apr 2010 17:22
Last Modified: 26 Jul 2020 01:55


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